Genomic analysis of multiresistant staphylococcus capitis associated with neonatal sepsis

GP Carter; JE Ussher; AG Da Silva; SL Baines; H Heffernan; TV Riley; R Broadbent; A Van Der Linden; J Lee; IR Monk; TP Stinear; BP Howden; DA Williamson

Journal article

Genomic analysis of multiresistant staphylococcus capitis associated with neonatal sepsis

GP Carter, JE Ussher, AG Da Silva, SL Baines, H Heffernan, TV Riley, R Broadbent, A Van Der Linden, J Lee, IR Monk, TP Stinear, BP Howden, DA Williamson

Antimicrobial Agents and Chemotherapy | AMER SOC MICROBIOLOGY | Published : 2018

DOI: 10.1128/AAC.00898-18

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Abstract

Coagulase-negative staphylococci (CoNS), such as Staphylococcus capitis, are major causes of bloodstream infections in neonatal intensive care units (NICUs). Recently, a distinct clone of S. capitis (designated S. capitis NRCS-A) has emerged as an important pathogen in NICUs internationally. Here, 122 S. capitis isolates from New Zealand (NZ) underwent whole-genome sequencing (WGS), and these data were supplemented with publicly available S. capitis sequence reads. Phylogenetic and comparative genomic analyses were performed, as were phenotypic assessments of antimicrobial resistance, biofilm formation, and plasmid segregational stability on representative isolates. A distinct lineage of S. ..

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Funding Acknowledgements

This study was supported by a grant from the William Sherriff Charitable Trust (to J.E.U.) and internal funding from the Department of Microbiology and Immunology at the University of Melbourne and The Institute of Environmental Science and Research, New Zealand. The National Health and Medical Research Council, Australia, funded Practitioner Fellowship GNT1105905 to B.P.H. and an Early Career Fellowship GNT1123854 to D.A.W.